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japonicum -infected mice, G-MDSC was found to inhibit Tfh cell proliferation, possibly through the programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway (255)

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Cafestol may protect against diabetes-associated myocardial fibrosis, given that it mitigates against increased collagen synthesis, transforming growth factor-1 production, and Smad2/3 phosphorylation (seen on exposure to high glucose conditions) in rat cardiac fibroblasts [69]