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Alejandra Arreola-Triana for her support in editing this manuscript, and Victor Mendoza for his assisting to images design

Furthermore, decreased NAD+ levels, potentially a consequence of reduced kynurenine, may contribute to fatigue by impairing energy production, and disrupting the coordination of circadian rhythms necessary for effective sleep (reviewed in Dehhaghi et al., 2022)

These effects occur in a minority of users and rarely require discontinuation

If GH-related effects such as improved sleep quality, recovery speed, or body composition changes plateau before the cycle ends, that is an early signal of receptor saturation