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Beyond the glutamate system, ketamine interacts with a range of other sites, including opioid receptors, albeit with lower affinity than with the NMDA receptor 15,16

They have emerged as key therapeutic targets in diabetes and obesity research , ranging from GLP-1 analogs like Semaglutide (Ozempic/Wegovy) to dual and triple agonists (Retatrutide) that synergistically enhance glycemic control and promote weight loss

Retatrutide is a novel triple-agonist peptide developed by Eli Lilly, targeting GIP, GLP-1, and glucagon receptors, showing significant promise in clinical trials for obesity and type 2 diabetes due to its potent effects on appetite, energy expenditure, and glycemic control