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Glutathione has gained popularity as a sought-after ingredient in skincare formulations due to its multifaceted benefits, including anti-inflammatory, antioxidant, depigmenting, and anti-aging properties

Free radicals are unstable molecules that can cause oxidative stressa process that damages cells and tissues over time

While both scenarios likely contribute to immune tolerance, it is generally believed that hot tumors may respond better to immune checkpoint inhibitors (ICIs) than cold tumors because the former have pre-existing cytotoxic cells potentially capable of recognizing tumor derived neoantigens.47 For cold tumors, on the other hand, antitumor immunity is likely abrogated at a much earlier stepmaking this subtype potentially more challenging to treat with ICIs

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