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Notably, compound 1d exhibited the most potent activity against Escherichia coli and Staphylococcus aureus with MIC ranges of 31.3125.0 g/mL and against Pseudomonas aeruginosa with MIC ranges of 375.0500.0 g/mL

In addition, glycine and glutamate deficiency also affects GSH synthesis to some extent [23]