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Clinical studies show measurable visceral fat reductions within 36 months of consistent 2 mg daily dosing, with continued benefit over 12 months when therapy is maintained

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However, a very small percentage of B12 from a supplemental dose is absorbed by passive diffusion, rather than by intrinsic factor, such that vegans can make up for taking B12 only once per day, or even only once per week, by taking larger doses than normally provided by food