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For example, in the SURMOUNT-4 trial, tirzepatide discontinuers were randomized to a placebo, and they were unaware whether they were receiving tirzepatide or not. In real-world settings, the most common reasons for discontinuation are cost or insurance-related issues, and side effects, with the former predominating, he added

In melanocytes, CAT primarily manages HO degradation, providing a critical defense against oxidative stress 57

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Hair thinning may resume if treatment is stopped