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Chang W, Hatch GM, et al

Patients with a history of significant sugar consumption may have established neural pathways that require more time to recalibrate

Gene expression on BDNF and SK-3 was quantified using real-time PCR, revealing that VPA reduced the expression BDNF, which plays a crucial role in synaptic plasticity and neuronal survival, and increased GSK-3, which is involved in neurodevelopment and neuroinflammation whereas crocin dose-dependently normalized both markers (Hosseini et al., 2025)

Given this fact, if vitamin C and niacinamide werent compatible, topical use of niacinamide would either do nothing or result in skin problemstodays studies are showing only benefits