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Executive summary RGA has quantified the expected mortality and morbidity impacts of incretin-based drugs, including GLP-1s, approved as anti-obesity medications (AOMs) and diabetes treatments in the US, UK, Canada, and Hong Kong

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In depression, the inflammatory phenotype is particularly associated with atypical symptoms, including increased sleep and appetite, potentially leading to weight gain and local inflammation and macrophage infiltration in the adipose tissue, creating a self-perpetuating inflammatory loop [81]

Slower Titration Option Some practitioners use a more gradual escalation with 2 mg increments every four weeks