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As expected by the increased striatal DA, pathways signifying activation of signalling by G-protein-coupled receptors, transmission across chemical synapses and calcium signalling were all positively enriched at 3 months in iSPN + mut (Supplementary Table 1a), whereas genes associated with metabolic pathways such as oxidative phosphorylation (OxPhos) and respiratory electron transport ATP synthesis were significantly downregulated in iSPN + mut compared to iSPN+wt at 3 months (Fig

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Lentiginous growth pattern The pattern of intra-epidermal growth of naevi and melanomas in which melanocytes are arranged mainly as individual units rather than as nests within the basilar epidermis

It also affects gene expression by increasing GLP-1 receptors and reducing hormone breakdown to keep GLP-1 levels active