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confirmed that TFAP2C regulated GPx1 expression by directly binding to the GPx1 promoter, which contains an AP-2 regulatory region, and the methylation of the CpG island in the GPx1 promoter region prevented the binding of TFAP2C by encompassing the AP-2 regulatory region [81]

Similarly, in a retrospective study of 80 patients with metastatic melanoma who received a combined CTLA-4 and a PD-1 inhibitor, patients who developed irAEs warranting treatment discontinuation were later rechallenged with a single-agent PD-1 inhibitor

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