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Acknowledgements This work was the result of using research equipment shared in MEXT Project for promoting public utilization of advanced research infrastructure (Program for supporting construction of core facilities) Grant Number [JPMXS0441200024]

Medicare historically limited GLP-1 coverage to diabetes and cardiovascular indications, explicitly excluding obesity treatments ( [21] )

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Keywords: tinnitus, hearing loss, auditory system, antidepressants, TCM Introduction Tinnitus, defined as the perception of sound in the absence of an external auditory stimulus, is a prevalent and often distressing condition with significant implications for global health