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Overall, we revealed that a high-affinity oxylipin-sensing OR plays key roles in metabolism

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Both Ozempic and the generic semaglutide products are approved by Health Canada for management of diabetes, but for years doctors prescribed it off-label for weight loss before manufacturer Novo Nordisk began selling Wegovy in Canada in 2024

Low-grade chronic inflammation and immunological imbalance facilitate a bidirectional association between obesity and immune-mediated dermatoses An excess of dysfunctional adiposity contributes to the inflammatory state that characterizes patients with obesity.14 As low-grade inflammation underlies obesity, PsO, and HS (Fig