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[Confidence: Medium] Organ-Specific Targeting: By isolating the hippocampus, the researchers confirmed that GHK-Cu can cross the blood-brain barrier (or bypass it via olfactory tracts) to modulate neuroinflammation and synaptic plasticity, which are critical bottlenecks in age-related cognitive decline

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It is characterized by noticeable and measurable cognitive deficits that are greater than typical age-related changes but not severe enough to significantly interfere with daily activities or independence