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The study quantified cytokines, neurotransmitters, oxidative stress markers and detoxification enzymes using ELISA-based assays, revealing that VPA exposure disrupted glutathione balance, increased IL-6, CYP450 and glutamate, and reduced serotonin and IFN-, while curcumin partially restored these alterations ( Furthermore, Yang and Bhandari employed a PPA-induced rat model of autism, using male-only Sprague-Dawley rats that received intracerebroventricular infusions of 1M PPA

The majority of the subjects (83.6%) showed improvement in global wrinkle scores, skin elasticity (via cutometer) and skin texture, tone, and radiance after 3 months of treatment

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4 Thus, defects in SLC25A39 induce severe disturbances in the mitochondrial GSH-import machinery contributing to neuronal degeneration