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Mice lacking Hmgcr in -cells exhibited low insulin concentrations and hyperglycemia attributable to decreases in both -cell mass and insulin secretion

Antioxidants are major in vivo and in situ defense mechanisms of the cells against oxidative stress [9, 13, 1517]

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75 Conversely, forced overexpression of CDO1 in breast cancer cells shifted the flux from glutathione synthesis towards cysteine catabolism, consequently increasing ROS levels and leading to reduced cell viability and growth