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After sifting through numerous gut hormones, the two researchers concentrated their efforts on glucagon because they knew it had multiple targets

Similar content being viewed by others Introduction Dimerization is essential in biological systems, playing a key role in regulating physiological functions and regulatory mechanisms of living organisms 1,2

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Importantly, Akt/PKB also phosphorylates forkhead transcription factors of the FOXO subfamily, and this leads to their inactivation and retention in cytoplasm[254, 255] resulting in a reduced transcriptional activity[256]