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The funnel plot appeared to be symmetrical (SI3 - Fig

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In addition, BBR also ameliorated glucosamine hydrochloride (Glcn) -induced IR and increased GLUT2 expression in a PPAR/FGF21-dependent manner which reduced T2DM induced hepatic lipid accumulation and pancreatic injury ( 5.2.3 AMP-activated protein kinase (AMPK) signaling pathway AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that plays a crucial role in regulating cellular metabolism and energy homeostasis, and is considered a potential therapeutic target for the treatment of DM (Entezari et al., 2022