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Integrating UGT inhibition data into the rule-of-two model significantly enhances the prediction accuracy for drug-induced liver injury (DILI) (119)

It has been possible to map the incretin function in humans in some detail owing to the availability of receptor antagonists for both hormones, namely exendin 9-39 for the GLP-1 receptor and the amidated GIP fragment GIP 3-30 amide for the GIP receptor [2]