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Abbreviations AD: Alzheimers disease ASD: Autism spectrum disorder BBB: Bloodbrain barrier BDNF: Brain-derived neurotrophic factor CNS: Central nervous system CRF: Corticotropin-releasing factor EAE: Experimental autoimmune encephalomyelitis ENS: Enteric nervous system FMT: Fecal microbiota transplantation GABA: Gamma-aminobutyric acid GLP-1: Glucagon-like peptide-1 HD: Huntingtons disease HPA axis: Hypothalamicpituitaryadrenal axis LPS: Lipopolysaccharide MGBA: Microbiotagutbrain axis MS: Multiple sclerosis PD: Parkinsons disease SCFAs: Short-chain fatty acids TMA: Trimethylamine TMAO: Trimethylamine N-oxide TNF-: Tumor necrosis factor-alpha Th17: T helper 17 cells Tregs: Regulatory T cells References Wilson DM III, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I

Riboflavin What it does General Riboflavin is a B-vitamin that assists several metabolic and antioxidant enzymes and helps convert food into usable energy

Such high GSSG concentrations are unlikely to occur in most subcellular compartments but could be reached in the secretory pathway or during titration experiments of transgenic cell lines with an upregulated GSSG transporter 35,63,64,77

Science 366 , eaax6624 (2019)