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As a result, real-world experiences with GLP-1 medications do not always follow the exact pattern seen in clinical trials

The evidence and the missing genetic layer The compound class carries a deep trial record: STEP for semaglutide in weight management (NEJM 2021), SURMOUNT for tirzepatide (NEJM 2022), and SURMOUNT-OSA for tirzepatide in obstructive sleep apnea (NEJM 2024)

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