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In about 17,600 adults with obesity and established cardiovascular disease but no diabetes, semaglutide cut major cardiovascular events by 20% over roughly 40 months. This is a secondary-prevention result in people who already had heart disease

When ROCK is inhibited with Y-27632, it causes a redistribution of F-actin, leading to decreased nuclear localization of YAP and reduced expression of Cgtf and Cyr61

Curiously, MTII increased myocardial fatty acid oxidation rates, whereas leptin had no effect on fatty acid oxidation rates (Figure 3D in Gava et al

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