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Mast cell degranulation also floods the system with histamine that must be conjugated (both N-methylated by HNMT intracellularly and oxidized by DAO extracellularly)

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In conclusion, this review synthesises current evidence on human exposure to PET MNPs, outlines toxic effects observed in vitro and in vivo, and identifies priority gaps to guide future research

Earlier, in vitro experiments demonstrated that -Amanitin could act either as an antioxidant or as a prooxidant depending on the treatment conditions and toxin concentration [151,153]