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The pharmacokinetic profiles of these formulations indicate that maximum plasma concentrations are typically attained within 1 to 3 days following SC administration, while steady-state plasma levels are generally achieved after 4 to 5 weeks of once-weekly dosing

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This process is especially useful during exercise, potentially improving endurance by preserving glycogen stores

However, tirzepatide significantly lowers blood sugar, so other diabetes medications, especially insulin and sulfonylureas, often need dosage reduction to prevent hypoglycemia