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In November 2022, the FDA banned the sale of NMN to investigate its potential as a new drug

Notably, bi-allelic MC4R mutation carriers had long-term outcomes as poor as those with bi-allelic LEPR or POMC mutations, suggesting that biallelic mutations in LMP genes generally lead to more severe impairment of surgical efficacy compared to heterozygous mutations

On the other hand, Stard7 deficiency in IECs is also associated with decreased levels of both plasmanyl and plasmenyl lipids, independently of the Apc status