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myalgic encephalomyelitis chronic fatigue syndrome long COVID chronic illness medications pharmacotherapy supplements complementary therapies integrative medicine clinical practice patterns primary care specialists practice-based research INTRODUCTION Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem neurologic disease characterized by the following 2015 criteria of the National Academy of Medicine: (1) profound fatigue/reduction in function of at least 6 months, (2) postexertional malaise, (3) unrefreshing sleep, and (4) cognitive changes and/or orthostatic intolerance