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Prior to use, allow REPATHA to warm to room temperature for at least 30 minutes for the prefilled single-dose SureClick autoinjector or prefilled single-dose syringe and for at least 45 minutes for the on-body infusor with prefilled cartridge if REPATHA has been refrigerated [see How Supplied/Storage and Handling (16)]

La mitocondria necesita grasa para generar energa, esta no puede entrar en forma de cidos grasos de cadena larga, se necesita un trasportador para estos cidos grasos y este es la carnitina

Dosing paradigms, route of administration, and exposure considerations Published in vivo experiments commonly use intraperitoneal (i.p.) administration at 50 mg/kg twice daily for 1228 days in adult male C57BL/6J or ob/ob mice, with cohorts kept at thermoneutrality and studied by indirect calorimetry (CLAMS) and body-composition analyses