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Inflammation & cytoprotection: models of inflammatory signaling, cytoprotection and stress responses

A well-run randomized Phase 2 study is strong evidence of an efficacy signal and a first read on short-to-medium-term safety in a selected population it is why the weight-reduction numbers are credible rather than anecdotal

PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024

Hair follicles need robust blood supply for nutrients and oxygen