The trade-off is that higher doses later in your protocol will require drawing larger volumes, potentially exceeding the 100-unit syringe capacity at doses above 1mg to 2.5mg depending on concentration
Exclusion criteria included other forms of diabetes mellitus, pregnancy or lactation, contraindications to GLP-1RAs, previous or ongoing treatment with pioglitazone and/or Sodium-glucose cotransporter-2 inhibitors (SGLT2i) and/or GLP-1RAs, inadequate ability to comply with follow-up or provide informed consent, implantable electronic devices (cardioverter defibrillators or pacemakers) contraindicating body composition assessment by segmental multifrequency bioelectrical impedance analysis (SMF-BIA- Seca mBCA 525), as indicated by the manufacturer (Seca GmbH & Co., KG, Hamburg, Germany), the use of oral contraceptives or corticosteroids, infection by viral hepatitis B and C, and excessive ethanol consumption (more than 30 grams/day in men and 20 grams/day in women)
Symptoms of hypokalemia (low potassium) may not always be apparent, so its important to keep up with any recommended laboratory monitoring by a medical professional
Any new cardiac symptoms, significant muscle weakness, or signs of dehydration warrant prompt medical evaluation and possible electrolyte testing