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[DOI] [PubMed] [Google Scholar] 33.Birn H., Willnow T.E., Nielsen R., Norden A.G.W., Bnsch C., Moestrup S.K., Nex E., Christensen E.I

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The compound's innovative design incorporates all 44 amino acids of human GHRH with a critical modification: the addition of a trans-3-hexenoic acid group attached to the amino-terminal tyrosine residue, which renders the peptide resistant to dipeptidylaminopeptidase 4 (DPP4) degradation while preserving full biological activity