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Specifically, a high-fat and high-sugar diet increased the -amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid to N-methyl-D-aspartic acid receptor current ratio in medium spiny neurons and prolonged spontaneous glutamate-mediated currents, increased DA release and slower DA reuptake in the striatum, and reduced MOR-mediated synaptic plasticity (73)

This energy exhaustion will further lead to the production of reactive oxygen species (ROS), apoptosis, and abnormal calcium homeostasis, which will promote epilepsy, thus forming a vicious circle (5)

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