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Our findings support previous research indicating that combining metformin and simvastatin enables a reduction in individual drug dosages, enhancing the safety profile of the treatment regimen

These questions demand rigorous, long-term studies

The intermediates from de novo lipogenesis in the liver will disrupt mitochondrial function and produce ROS, and then cause endoplasmic reticulum (ER) stress, ultimately leading to inflammation, and the broken cells releasing cytokines will cause more cell death ( The excess free fatty acids (FFAs) and de novo lipogenesis would break the homeostasis of lipid metabolism

Reviews suggest that improvements in other conditions, like blood pressure and knee pain, are mostly linked to weight loss rather than a strong direct drug effect