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Eating smaller, more frequent meals throughout the day rather than large portions can reduce gastrointestinal discomfort

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Compared with genetic approaches highlighting the importance of single GLP-1R populations, this broader approach is important in determining the functional mechanisms of GLP-1RAs and evaluating the potential translational value of other mechanistic principles for the treatment of obesity

Or if someone has lost a huge amount but still remains with severe obesity, sometimes bariatric surgery is a consideration for the remaining weight but thats a whole other pathway and usually the GLP-1 is tried first to see how far one can get