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Once discontinued, many patients experience appetite rebound, making sustained weight loss challenging

Two phase II trials - one in a population with obesity (without T2D) [45], and a second in a population with T2D and overweight/obesity [46], have recently been published and their key findings are presented below (Table 1)

This action helps reduce liver stress and supports the organ's natural detoxification processes

Their anti-inflammatory properties are also critical, as they can inhibit inflammatory factors such as TNF- , IL-6, and IL-1 (e.g., quercetin, ellagic acid, curcumin, ferulic acid) and suppress NF-B through AMPK pathway regulation, which is crucial for mitigating the chronic low-grade inflammation associated with obesity (19, 28)