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The number of C-CASP3-positive SGNs was downregulated in the presence of ebselen, while it was further increased in gpx1 / mice compared with the peroxynitrite-only group (Figure 4B)

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Notably, several DUBs identified in our study, including ATXN3, UCHL1, UCHL5, and YOD1, have been previously implicated in neurodegenerative disorders such as spinocerebellar ataxia, Alzheimers disease, and Parkinsons disease 12,22,23,24,62,63 , underscoring the relevance of DUB activity loss in the context of aging and age-related neurodegeneration

ARV-110: an oral androgen receptor PROTAC degrader for prostate cancer