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Bulk RNA-sequencing of liver and WAT RNA extraction, library construction and sequencing To assess changes in gene expression in peripheral tissues, liver and inguinal WAT collected from DIO Gipr Syn/ and Glp1r Wnt1/ mice with mGIPR-Ab/P1 peptideantibody conjugate treatment (Figs

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4a), we assumed that MEK1/2 phosphorylation might be induced by inhibition of AKT activation