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Whilst often mild and self-limiting, persistent or worsening injection site reactions warrant medical review, as they may indicate developing sensitivity to the medication

Through these mechanisms, GLP-1RAs activate multiple pathways, reduce inflammation, improve mitochondrial function, modulate proteostasis, and promote synaptic plasticity (4852), a profile well suited to the multifactorial nature of NDDs

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Moreover, in animal models of neuroinflammation, GLP-1RAs have demonstrated antioxidant, antiapoptotic, and neurotrophic effects