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[] Broccoli sprouts and SFN are assumed to have preventive and suppressive action against PCa

A crosstalk between apoptosis and autophagy exists, and the interaction of anti-apoptotic regulators such as Bcl-2 and Bcl-xl suppresses the autophagy promoter Beclin-1 activity, resulting in autophagy inhibition (Pattingre et al., 2005)

However, none of these compounds have been tested in human Alzheimer patients, and the transition from animal models to human clinical outcomes is notoriously difficult in neurodegenerative disease

It is important to mention that the follow-up duration of Wegovy is only 3 years, whereas other GLP-1 RA medications were studied for 5 years