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The chart separates that laboratory snapshot from the effect of sustained dosing

Abbreviations AAA: Aromatic amino acids ACLF: Acute-on-chronic liver failure ALF: Acute liver failure ALT: Alanine aminotransferase AST: Aspartate aminotransferase AMPA: Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid AT2A: Alzheimer type 2 astrocytes BCAA: Branched-chain amino acids BDL: Bile duct ligation BBB: Blood-brain barrier BRTO: Balloon-occluded retrograde transvenous obliteration BZD: Benzodiazepines CHESS: Clinical HE staging scale cGMP: Cyclic guanosine monophosphate CLD: Chronic liver disease CLF: Chronic liver failure cMyc: Cellular myelocytomatosis oncogene COX2: Cyclooxygenase-2 CXCL1: CXC motif chemokine ligand 1 ECs: Endothelial cells ETA: Etanercept EVs: Extracellular vesicles FMT: Fecal microbiota transplantation GABA: Gamma-aminobutyric acid GAD67: Glutamate decarboxylase 67 GAT1: GABA transporter 1 GD: Gut microbiota dysbiosis GFAP: Glial fibrillary acidic protein GI: Gastrointestinal GM: Gut microbiota GMF: Glia maturation factor GS: Glutamine synthetase HE: Hepatic encephalopathy HRQoL: Health-related quality of life ICH: Intracranial hypertension ICP: Intracranial pressure IL: Interleukin IR: Interventional radiology ISHEN: International society for hepatic encephalopathy and nitrogen Metabolism JNK1/2: c-Jun N-terminal kinases 1/2 LOLA: L-ornithine-L-aspartate LT: Liver transplantation MELD: Model for end-stage liver disease mHE: Minimal hepatic encephalopathy MMP: Metalloproteinase MSC: Mesenchymal stem cells NAD: Non-absorbable disaccharides NH 3 : Ammonia NMDA: N-methyl-D-aspartate NO: Nitric oxide OP: L-ornithine phenylacetate PB: Sodium phenylbutyrate PCA: Portacaval anastomosis PGE2: Prostaglandin-2 PROs: Patient-reported outcomes PVE: Portal vein embolization RCT: Randomized controlled trials SIBO: Small intestinal bacterial overgrowth SIRS: Systemic inflammatory response syndrome TAA: Thioacetamide TAD: Tadalafil TIPS: Transjugular intrahepatic portosystemic shunt TNF-: Tumor necrosis factor-alpha UC-MSC: Umbilical cord-derived mesenchymal stem cell WHC: West haven criteria References Tong XY, Hussain H, Shamaladevi N, Norenberg MD, Fadel A, El Hiba O, et al

the study subjects were not clearly diagnosed with DOR/POR, or the study population was highly heterogeneous