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Several companies have GLP-1/glucose-dependent insulinotropic polypeptide (GIP) dual agonists in phase 1 studies, including SCO-094 (Scohia Pharma), VK2735 (Viking Therapeutics) and CT-388 (Carmot Therapeutics)

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PHDis have also been shown to act on carbohydrate metabolism by activating neoglucogenesis from lactate in the Cori cycle [48]