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I was sitting with my wife, M., and a friend visiting from Munich in front of our favorite restaurant on a summers evening in Berlin, and after a light dinner I tapped the last American Spirit out the pack that I had shared with our friend

The cumulative impact of these chemicals over time can lead to chronic lung diseases and significantly reduce life expectancy

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I think our work is super exciting because we had the power to directly examine the effects of smoking in tissues such as lung and colon, which are highly relevant in the pathophysiology of smoking. Understanding defense mechanisms to smoke Many of the CpGs identified in the tissues matched up with ones identified in previous studies using blood samples, including genes involved in detoxification or transformation of foreign chemicals so they can be removed from the body