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I suffer from depression anyway, so I have been very cautious about the dosage

Coping With: Bone Thinning and Osteoporosis When taken over long periods of time, prednisone can cause issues with your bone health, which, though rarely, can include osteonecrosis (bone death) that causes pain around your joints in particular or osteoporosis that leads to thinner and more brittle bones that fracture easily

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For spider bites, keep applying until the wound is healed