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In fact, tobacco nitrate levels have been previously reported to correlate with the formation of non-specific volatile nitrosamines (e.g., N-nitrosodimethylamine, N-nitroso-diethylamine, N-nitrosoethylmethyl- amine, etc.), and non-volatile Tobacco-Specific Nitrosamines (TSNAs) such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, nicotine-derived nitrosamine ketone) which have been associated with carcinogenicity of tobacco smoke [30, 31]