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Systemic adeno-associated virus serotype (AAV) 9-mediated delivery of the circular RNA circAASS restored mitophagy and mitochondrial biogenesis in AKI models by both enhancing PINK1 expression and stabilizing PGC-1, resulting in reduced tubular injury and long-term fibrosis (Ma et al., 2025)

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Detailed insights into mass balance, unit operations, raw material requirements, and the manufacturing process flow are also provided to ensure a clear understanding of the production setup

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