why is e cigarettes harmful Fast facts on the effects of e-cigarettes and vaping Heated Tobacco Products, Cigarettes, and

[92] Corticotropin-releasing factor, Neuropeptide Y, orexins, and norepinephrine are involved in nicotine addiction

E-cig fluid contains numerous chemicals known to be toxic to the respiratory system, such as carbonyl compounds, aldehydes, fine particulate matter, metals, propylene glycol, glycerol, formaldehyde, volatile organic compounds (VOCs), and flavoring chemicals 7,8,9,10,11,12,13,14,15,16,17 , and bacterial endotoxins and fungal glucans 18

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Methods Identification of Studies We searched PubMed, Scopus, and Web of Science up until August 1, 2015 using the following search terms: depressi*, anxi*, smok*, tobacco, nicotine, cigarette, caus*, cohort, prospective, longitudinal