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The tobacco is germinated in cold frames or hotbeds and then transplanted to the field until it matures

Precisely, methylation is what allows different genes to be expressed in different tissues, since the DNA sequence is the same in all cells, but methylation is different depending on the tissue

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However, the availability of e-cigarettes attenuated the size of that link: the more available e-cigarettes become, the less the ITTP market share rises in response to tax-driven price increases for conventional cigarettes. 145 Prieger et al., Impact of Ecigarette Regulation