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Like e-cigarettes and heated tobacco products, heated alternatives are considered as a safer replacement for combusted tobacco products, as they are heat-not-burn products without producing harmful smoke

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Carcinogenic toxicants contained in cigarette smoke, such as TSNAs, metabolites of polycyclic aromatic hydrocarbons (PAH), free radicals [including reactive oxygen species (ROS) and reactive nitrogen species (RNS)], and various aldehydes, will cause genetic damage that can lead to the loss of normal cellular growth control mechanisms and cell proliferation [16,17,18]

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