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We are hopeful that mRNA vaccines could not only improve outcomes for patients being treated with immunotherapies but also bring the benefits of these therapies to patients with treatment-resistant disease. A multi-center, randomized Phase III trial currently is being designed to validate these findings and investigate whether COVID mRNA vaccines should be part of the standard of care for patients receiving immune checkpoint inhibition

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The authors recognized in particular that they lacked tangible evidence concerning the dangers of most of the products according to the majority of the criteria used (lack of hard evidence for the harms of most products on most of the criteria)

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