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This study examined the following characteristics related to smoking cessation interventions: the number of counseling sessions, the use of pharmacotherapeutic smoking cessation aids (nicotine replacement therapies, NRTs) such as nicotine patches, gum, and lozenges, and the use of prescription medicines for smoking cessation (varenicline and bupropion)

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This complement activation by smokeless tobacco extracts suggests a potential mechanism for initiating inflammation of the oral mucosa in users of these products (89)