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Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist with high oral bioavailability and CNS penetration in the rat

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Experiencing withdrawal symptoms when attempting to stop smoking: When attempting to stop smoking, one may experience physical and emotional withdrawal symptoms such as anxiety, irritability, strong mood swings, intense cravings, restlessness, difficulty concentrating, depressed mood, frustration, diarrhea, constipation, increased appetite, or insomnia